Department of Surgery, The University of Chicago, Chicago.
J Exp Med. 1933 Sep 30;58(4):393-400. doi: 10.1084/jem.58.4.393.
Evidence is presented that the proliferating gall bladder epithelium in the dog and guinea pig is capable of stimulating bone formation in certain connective tissues such as the abdominal wall. Other connective tissue areas such as the subepithelial connective tissue of the gall bladder and urinary bladder do not share in this tissue reaction and resist the bone stimulus of the epithelium. The formation of bone in these circumstances is thus biphasic. A difference between connective tissues morphologically identical can be proven physiologically, by their response to the osteogenic stimulus of appropriate epithelia. Calcium carbonate microliths occurred in the mucus of the occluded gall bladder in which there was transplanted connective tissue forming part of the wall.
有证据表明，在狗和豚鼠中，增殖的胆囊上皮能够刺激某些结缔组织（如腹壁）形成骨。其他结缔组织区域，如胆囊和膀胱的上皮下结缔组织，并不参与这种组织反应，并且抵抗上皮的骨刺激。在这种情况下，骨的形成是两相的。通过适当上皮的成骨刺激对其的反应，在形态上相同的结缔组织之间的差异可以在生理学上得到证明。碳酸钙微石出现在被阻塞的胆囊的粘液中，其中有移植的结缔组织形成壁的一部分。
