Hospital of The Rockefeller Institute for Medical Research.
J Exp Med. 1937 Jun 30;66(1):1-14. doi: 10.1084/jem.66.1.1.
From the results of the experiments described in this paper it is obvious that large amounts of elementary bodies of myxoma can be obtained in a relatively pure state by means of the methods used. Furthermore, it is evident that infectious myxomatosis is a viral disease in which elementary bodies of the same order of magnitude as vaccinal elementary bodies play a conspicuous rô1e in that they either represent the etiological agent or are intimately associated with it. The bodies are specifically agglutinated by antimyxoma serum and are agglutinated to a less extent by serum from rabbits convalescing from fibroma, a disease closely related to myxoma. In virus-free filtrates of emulsions prepared from infected skin there is a soluble precipitinogen or precipitinogens specific for the malady. Moreover, a specific precipitinogen or precipitinogens are demonstrable in virus-free serum of animals acutely ill as a result of extensive infection with myxoma virus. It is believed that this is the second viral disease, yellow fever (14) being the first, in which a specific soluble antigen free from virus has been found in the serum of ill animals.
从本文所述实验的结果可以明显看出，通过所使用的方法可以获得大量相对纯净的黏液瘤病毒的初级粒子。此外，传染性黏液瘤病显然是一种病毒性疾病，在这种疾病中，与疫苗初级粒子同等级的初级粒子起着显著的作用，因为它们要么代表病原体，要么与其密切相关。这些粒子可以被抗黏液瘤血清特异性凝集，而且也可以被来自从纤维瘤（一种与黏液瘤密切相关的疾病）中康复的兔子的血清低度凝集。在从受感染皮肤制备的乳液的无病毒滤液中，存在针对该疾病的特异性沉淀原或沉淀原。此外，在因广泛感染黏液瘤病毒而急性患病的动物的无病毒血清中，可以证明存在特异性沉淀原或沉淀原。据信，这是继黄热病（14）之后第二种发现患病动物血清中存在无病毒的特异性可溶性抗原的病毒性疾病。
