恶性贫血患者尿液中缺乏一种存在于正常人尿液中的蚊虫生长因子。
THE ABSENCE FROM THE URINE OF PERNICIOUS ANEMIA PATIENTS OF A MOSQUITO GROWTH FACTOR PRESENT IN NORMAL URINE.
机构信息
Department of Animal and Plant Pathology, The Rockefeller Institute for Medical Research, Princeton, New Jersey, and the Hospital of The Rockefeller Institute for Medical Research, New York.
出版信息
J Exp Med. 1938 Feb 28;67(3):469-80. doi: 10.1084/jem.67.3.469.
Extracts prepared from the urine of normal persons or patients with aplastic anemia or leukemia contain a substance, possibly flavine or a flavine compound, which under suitable conditions of test enhances the growth of larvae of the mosquito, Aëdes aegypti. This substance is lacking, or is present in much smaller amount, in extracts from the urine of pernicious anemia patients showing symptoms of the disease. Extracts from the urine of the same patients after adequate treatment contain as much of the substance as normal urine extracts.
从正常人、再生障碍性贫血患者或白血病患者的尿液中提取的物质，可能是核黄素或核黄素化合物，在合适的试验条件下，可促进埃及伊蚊幼虫的生长。在患有表现出疾病症状的恶性贫血患者的尿液提取物中，这种物质缺乏或含量较少。经过适当治疗后，来自同一患者的尿液提取物中含有与正常尿液提取物相同量的这种物质。
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