由饮食中过量半胱氨酸引起的肝硬化。
CIRRHOSIS OF THE LIVER CAUSED BY EXCESS DIETARY CYSTINE.
机构信息
Research Service, First Division, Welfare Hospital, Department of Hospitals, City of New York, and the Department of Medicine, College of Physicians and Surgeons, Columbia University, New York.
出版信息
J Exp Med. 1941 Jan 31;73(2):161-72. doi: 10.1084/jem.73.2.161.
Abstract
- Cystine fed to young albino rats as 10 per cent of the diet resulted in: (a) Portal hemorrhagic necrosis, resembling eclampsia, within 3 or 4 days. (b) A high mortality rate. (c) Fatty infiltration of hepatic cells in all rats surviving the initial acute lesion. (d) Cirrhosis of the liver in rats surviving more than 2 weeks. 2. 5 per cent dietary cystine produced marked fatty infiltration of the liver, followed by portal hemorrhagic necrosis. Cirrhosis was present in one of the two rats on the diet for 6 weeks. 3. The livers of rats fed 5 or 10 per cent cystine diets followed by the McCollum stock diet, showed evidence of residual cellular damage, and of regeneration as shown by mitotic figures. 4. In this series of 30 rats on excess dietary cystine, a renal lesion was found in only one case.
摘要
以 10%的饮食量将胱氨酸喂给幼龄白化大鼠，结果在 3 或 4 天内：(a) 发生类似于子痫的门脉性出血性坏死。(b) 死亡率高。(c) 所有幸存初始急性病变的大鼠的肝细胞脂肪浸润。(d) 超过 2 周存活的大鼠发生肝硬化。
5%饮食胱氨酸导致肝脏明显脂肪浸润，随后发生门脉性出血性坏死。在食用该饮食 6 周的两只大鼠中，有一只出现肝硬化。
用 McCollum 储备饮食喂养 5%或 10%胱氨酸饮食的大鼠的肝脏显示出细胞损伤的残余证据，以及有丝分裂图所示的再生。
在这一系列 30 只摄入过量饮食胱氨酸的大鼠中，仅在一例中发现肾脏病变。
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