Laboratories of The Rockefeller Institute for Medical Research.
J Exp Med. 1947 Apr 30;85(5):499-514. doi: 10.1084/jem.85.5.499.
A method for detoxifying Type Z and sp. Newcastle Sh. paradysenteriae (Flexner) has been described. This procedure involves exposing the bacilli at pH 5.0 to 0.01 M periodic acid. Microorganisms treated with this reagent for an appropriate time interval lose approximately 90 per cent of their toxicity, yet they are capable of eliciting in experimental animals antibodies effective against the unaltered organisms.
已经描述了一种解毒 Z 型和 sp.纽卡斯尔 Sh. 痢疾杆菌(Flexner)的方法。该程序涉及将细菌在 pH 值为 5.0 至 0.01 M 过碘酸的条件下暴露。用该试剂处理适当时间间隔的微生物,大约失去 90%的毒性,但它们能够在实验动物中引起针对未改变的生物体有效的抗体。