生物活性蛋白以及西方马脑脊髓炎病毒被高碘酸灭活。
The inactivation of biologically active proteins, and the virus of western equine encephalomyelitis by periodic acid.
作者信息
GOEBEL W F, OLITSKY P K, SAENZ A C
出版信息
J Exp Med. 1948 May 1;87(5):445-55. doi: 10.1084/jem.87.5.445.
Abstract
The action of periodic acid on two biologically active proteins, crystalline ribonuclease and pneumococcus Type III immune globulin, and on the virus of Western equine encephalomyelitis has been studied. The biological activity of the two proteins and the pathogenic action of the virus were destroyed by the reagent; the specific antigenicity of the immune globulin was retained, however, but that of the equine virus was lost. The bearing of these reactions on the chemical alteration of the respective substances has been discussed.
摘要
研究了高碘酸对两种生物活性蛋白（结晶核糖核酸酶和Ⅲ型肺炎球菌免疫球蛋白）以及西部马脑脊髓炎病毒的作用。该试剂破坏了这两种蛋白的生物活性以及病毒的致病作用；然而，免疫球蛋白的特异性抗原性得以保留，但马病毒的特异性抗原性丧失。讨论了这些反应对各物质化学变化的影响。
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