金黄色葡萄球菌的特异性凝固酶。
SPECIFIC COAGULASES OF STAPHYLOCOCCUS AUREUS.
机构信息
Departments of Preventive Medicine and of Medicine, School of Medicine, Western Reserve University, and the University Hospitals, Cleveland.
出版信息
J Exp Med. 1950 Feb 28;91(3):295-307. doi: 10.1084/jem.91.3.295.
Three staphylococcal coagulases termed I, II, and III were differentiated by measuring the antibody titer of human sera. Coagulases I and II are antigenically distinct; coagulase III appears to be related to both coagulases I and II. These results were confirmed by specific neutralization experiments. These observations emphasize the importance of employing the correct type of coagulase in studying the role of this substance in the pathogenesis of staphylococcal infections. Preliminary observations in animals indicate that specific anticoagulase develops following induced infections. The role of this antibody in the recovery mechanism remains to be determined.
三种葡萄球菌凝固酶，即 I、II 和 III，通过测量人血清中的抗体滴度来区分。凝固酶 I 和 II 在抗原性上是不同的；凝固酶 III 似乎与凝固酶 I 和 II 都有关。这些结果通过特异性中和实验得到了证实。这些观察结果强调了在研究这种物质在葡萄球菌感染发病机制中的作用时使用正确类型的凝固酶的重要性。在动物中的初步观察表明，在诱导感染后会产生特异性的抗凝酶。这种抗体在恢复机制中的作用仍有待确定。
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