Eldridge R. Johnson Foundation for Medical Physics, University of Pennsylvania, Philadelphia.
J Gen Physiol. 1941 Nov 20;25(2):263-73. doi: 10.1085/jgp.25.2.263.
Analytical diffusion has been applied to a study of influenza A virus in mouse lung, influenza A virus in the extra-embryonic fluids of the chick, and mouse encephalomyelitis virus in mouse brain. The results from influenza in mouse lung suggested that about 99 per cent of the infectivity was present in particles 200 mmicro in diameter, and 1 per cent in particles 6 mmicro in diameter. The results from influenza in extra-embryonic fluids indicated that the preparation was inhomogeneous and that the smallest virus units were about 6 mmicro in diameter. The results from mouse encephalomyelitis virus indicated that the preparation was also inhomogeneous, with 10 per cent of the infectivity in particles about 15 mmicro in diameter. It has been suggested that in virus preparations normal colloidal particles can act as carriers of much smaller virus units.
分析扩散已应用于对鼠肺中的甲型流感病毒、鸡胚外液中的甲型流感病毒以及鼠脑中的鼠脑脊髓炎病毒的研究。来自鼠肺中流感病毒的结果表明，约 99%的感染力存在于直径 200 微米的颗粒中，而 1%存在于直径 6 微米的颗粒中。来自胚胎外液中流感病毒的结果表明，该制剂不均匀，最小的病毒单位约为 6 微米。来自鼠脑脊髓炎病毒的结果表明，该制剂也不均匀，约 15 微米的颗粒中有 10%的感染力。有人认为，在病毒制剂中，正常胶体颗粒可以作为更小病毒单位的载体。
