Department of Physiology, School of Medicine, University of Minnesota, Minneapolis.
J Gen Physiol. 1947 Mar 20;30(4):367-74. doi: 10.1085/jgp.30.4.367.
The adaptive fermentation of galactose by yeast is inhibited by fluoride and azide. At sufficiently low concentrations, however, it is stimulated. From a mathematical analysis, using the known fact that fluoride inhibits the enzymes enolase and adenosinetriphosphatase, it is possible to infer the existence of such stimulation. Conditions for this effect are derived which relate the sensitivities of the enzymes to the poison with the rate constants of the various reactions in the fermentation chain.
酵母的半乳糖适应性发酵受到氟化物和叠氮化物的抑制。然而，在足够低的浓度下，它会受到刺激。通过使用已知的氟化物抑制烯醇酶和三磷酸腺苷酶的事实进行数学分析，可以推断出这种刺激的存在。推导出了这种效应的条件，这些条件将酶对毒物的敏感性与发酵链中各种反应的速率常数联系起来。
