温度对兔心室肌收缩和离子交换的影响：与主动状态控制的关系。
The Effects of Temperature upon Contraction and Ionic Exchange in Rabbit Ventricular Myocardium : Relation to control of active state.
机构信息
Departments of Physiology and Medicine and the Los Angeles County Cardiovascular Research Laboratory, University of California at Los Angeles Center for the Health Sciences, Los Angeles, California 90024.
出版信息
J Gen Physiol. 1968 Sep 1;52(3):682-713. doi: 10.1085/jgp.52.3.682.
The mechanical responses (active and resting tension, dP/dt, TPT) and ionic exchange characteristics (Ca(++), K(+), Na(+)) which follow upon a variation in temperature, rate, and K(+) were studied in the rabbit papillary muscle and arterially perfused rabbit interventricular setpum. Abrupt changes in temperature provided a means of separating the contributions of rate of development (intensity) of active state and duration of active state to total active tension development (approximated by isometric tension). Threefold changes in duration of active state with proportional changes in active tension can be induced without evidence for alteration of Ca(++), K(+), or Na(+) exchange. Abrupt cooling produced a moderate ( approximately 15%) increase of dP/dt which suggests an augmentation of active state intensity. Evidence is presented to suggest that this increase of dP/dt is based upon an increase in membrane Ca(++) concentration which occurs secondary to inhibition of active Na(+) transport. The alterations in ionic exchange and active state produced by variation of temperature are discussed in terms of a five-component control system.
在兔乳头状肌和动脉灌注兔室间隔中，研究了温度、速率和K(+)变化后机械反应（主动张力和静息张力、dP/dt、TPT）和离子交换特性（Ca(++）、K(+)、Na(+)）。温度的突然变化提供了一种分离主动状态发展（强度）的速率和主动状态持续时间对总主动张力发展（通过等长张力近似）的贡献的方法。在没有证据表明 Ca(++)、K(+)或 Na(+)交换改变的情况下，可以诱导主动状态持续时间的三倍变化，同时保持主动张力的比例变化。突然冷却会导致 dP/dt 适度（约 15%）增加，这表明主动状态强度增加。有证据表明，dP/dt 的增加是基于膜 Ca(++)浓度的增加，这是由于主动 Na(+)转运的抑制而发生的。本文根据一个五元件控制系统讨论了温度变化引起的离子交换和主动状态的改变。
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