Institute of Basic Medical Sciences and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Stem Cells Dev. 2010 Aug;19(8):1267-75. doi: 10.1089/scd.2009.0196.
The recent findings indicate that under conditions of severe tubular injuries, transplantation of mesenchymal stem cells (MSCs) may be a promising treatment in acute kidney diseases; nevertheless, the underling mechanism is still under debate. To investigate the differentiation characteristics and the role of MSCs in renal tubular injury, human adipose-derived MSCs (hAD-MSCs) were transplanted into ischemia-reperfusion (I/R) kidneys in C57BL/6 mouse model. Results showed that hAD-MSCs were able to differentiate toward renal tubular epithelium at an early stage of injuries. The differentiated donor cells replaced the vacant space left over by the dead cells, contributed to maintenance of structural integrity and proceeded to a subsequent tissue repair process. Furthermore, MSCs as supportive cells may promote repair via secreting cytokines. The differentiation and replacement of MSCs at an extremely early stage play important roles for the subsequent self-repair and -renewal of functional cells. Direct differentiation of MSCs, as an important mechanism of injured kidney repair, warrants further investigation.
最近的研究结果表明，在严重肾小管损伤的情况下，间充质干细胞（MSCs）的移植可能是急性肾脏疾病的一种有前途的治疗方法；然而，其潜在的机制仍存在争议。为了研究 MSCs 在肾小管损伤中的分化特征和作用，将人脂肪来源的间充质干细胞（hAD-MSCs）移植到 C57BL/6 小鼠模型的缺血再灌注（I/R）肾脏中。结果表明，hAD-MSCs 能够在损伤的早期向肾小管上皮分化。分化的供体细胞取代了死亡细胞留下的空位，有助于维持结构完整性，并进行随后的组织修复过程。此外，MSCs 作为支持细胞，可能通过分泌细胞因子来促进修复。MSCs 在极早期的分化和替代对于随后的功能细胞的自我修复和更新起着重要作用。MSCs 的直接分化，作为肾脏损伤修复的重要机制，值得进一步研究。
