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Expert Opin Pharmacother. 2009 Nov;10(16):2581-92. doi: 10.1517/14656560903304063.
OBJECTIVE: This study's objective was to review the literature on the epidemiological and economic burden and treatment of chronic low back pain (CLBP) in France, Germany, Italy, Spain and the UK. METHODS: A literature search was conducted for 1997 - 2007, focusing on CLBP burden and treatment in the countries of interest. RESULTS: The literature search yielded 1552 articles; 23 sources were included in this review. General population prevalence estimates for CLBP were available for two countries: 5.91% (Italy) and 6.3 - 11.1% (UK). Resource utilization estimates were available for Germany, Italy, Spain and the UK. Patients visited general practitioners and osteopaths. Annual direct costs of low back pain were available only for Germany: > euro 7000 per person. Work absenteeism accounted for 75% of the total per-patient cost of low back pain in Germany. The five identified treatment guidelines recommended a multimodal approach. Recommended pharmacotherapies included NSAIDs, muscle relaxants, analgesics and anesthetics, and opioids. CONCLUSIONS: Prevalence estimates varied, possibly owing to differences in diagnostic criteria and populations studied. Little is known about CLBP's economic burden. Treatment guidelines recommended multimodal treatment.
目的：本研究旨在回顾法国、德国、意大利、西班牙和英国有关慢性下背痛（CLBP）的流行病学、经济负担和治疗的文献。
方法：对 1997 年至 2007 年的文献进行了检索，重点是研究国家的 CLBP 负担和治疗情况。
结果：文献检索共获得 1552 篇文章，其中 23 篇纳入本综述。有两个国家提供了 CLBP 一般人群患病率的估计值：5.91%（意大利）和 6.3-11.1%（英国）。德国、意大利、西班牙和英国提供了资源利用情况的估计值。患者就诊于全科医生和整骨医生。仅在德国提供了慢性腰痛的年度直接成本：每人超过 7000 欧元。德国慢性腰痛每位患者总成本的 75%是由于旷工造成的。确定的 5 项治疗指南建议采用多模式方法。推荐的药物治疗包括 NSAIDs、肌肉松弛剂、镇痛药和麻醉剂以及阿片类药物。
结论：患病率估计值存在差异，可能是由于诊断标准和研究人群的不同。关于 CLBP 的经济负担知之甚少。治疗指南建议采用多模式治疗。
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