Department of Paediatrics, CHA University School of Medicine, Seongnam, Korea.
Clin Exp Dermatol. 2010 Aug;35(6):593-8. doi: 10.1111/j.1365-2230.2009.03635.x. Epub 2009 Oct 23.
B cell-activating factor (BAFF) is a tumour necrosis factor superfamily member best known for its role in the survival and maturation of B cells. BAFF activity is seen in naïve and effector/memory T cells.
To investigate the level and role of BAFF in serum of patients with atopic dermatitis (AD).
Levels of serum BAFF, a proliferation-inducing ligand (APRIL) and total serum IgE level, and total eosinophil count were measured in 245 children.
Patients were characterized as having atopic eczema (AE) (n = 90) or non-AE (n = 77); the remainder were healthy control subjects (n = 78). Serum BAFF level in children with AE (1625.04 +/- 708.32 pg/mL) was significantly higher than in non-AE children (1194.69 +/- 448.44 pg/mL, P < 0.0001) or healthy controls (1062.89 +/- 444.74 pg/mL, P < 0.0001). Serum APRIL level was not different between the three groups. Serum BAFF level significantly correlated with total serum IgE level (gamma = 0.42, P < 0.0001) and total eosinophil count. It was also positively correlated with serum BAFF and egg-specific IgE level (gamma = 0.252, P = 0.045) in AE.
Serum BAFF level is high in AE and might be a useful marker for AE.
B 细胞激活因子（BAFF）是肿瘤坏死因子超家族成员，以其在 B 细胞存活和成熟中的作用而闻名。BAFF 活性可见于幼稚和效应/记忆 T 细胞中。
研究特应性皮炎（AD）患者血清中 BAFF 的水平和作用。
在 245 名儿童中测量了血清 BAFF、增殖诱导配体（APRIL）和总血清 IgE 水平以及总嗜酸性粒细胞计数。
患者分为特应性湿疹（AE）组（n = 90）和非 AE 组（n = 77）；其余为健康对照组（n = 78）。AE 患儿血清 BAFF 水平（1625.04 +/- 708.32 pg/mL）明显高于非 AE 患儿（1194.69 +/- 448.44 pg/mL，P < 0.0001）或健康对照组（1062.89 +/- 444.74 pg/mL，P < 0.0001）。三组血清 APRIL 水平无差异。血清 BAFF 水平与总血清 IgE 水平呈显著正相关（gamma = 0.42，P < 0.0001）和总嗜酸性粒细胞计数。它还与 AE 中血清 BAFF 和鸡蛋特异性 IgE 水平呈正相关（gamma = 0.252，P = 0.045）。
AE 患者血清 BAFF 水平升高，可能是 AE 的有用标志物。
