人造抗体。
Man-made antibodies.
作者信息
Winter G, Milstein C
机构信息
MRC Laboratory of Molecular Biology, Cambridge, UK.
出版信息
Nature. 1991 Jan 24;349(6307):293-9. doi: 10.1038/349293a0.
DOI:10.1038/349293a0
PMID:1987490
Abstract
Monoclonal antibodies can now be genetically engineered and endowed with new properties. In the future, gene technology could enable antigen-binding fragments to be made by exploiting repertoires of variable domain genes derived from immunized animals and expressed in bacteria. How readily can this approach be extended to production of 'in vitro' repertoires of variable domain genes, and obviate the immunization of animals?
摘要
单克隆抗体现在可以通过基因工程进行改造并赋予新的特性。未来，基因技术或许能够利用源自免疫动物并在细菌中表达的可变结构域基因文库来制备抗原结合片段。这种方法能多容易地扩展到可变结构域基因的“体外”文库制备，并避免对动物进行免疫呢？
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