Bollenbach Tobias, Kishony Roy
Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
Cell. 2009 Oct 30;139(3):460-1. doi: 10.1016/j.cell.2009.10.005.
Why is a particular architecture for a pathway chosen over seemingly equivalent alternatives? Cağatay et al. (2009) use a synthetic biology approach to show that fluctuations--or noise--in protein levels may play a key role in determining which network design is selected during evolution.
为什么会选择某一种特定的信号通路架构，而不是看似等效的其他架构呢？恰加泰等人（2009年）采用合成生物学方法表明，蛋白质水平的波动——即噪声——在决定进化过程中选择哪种网络设计时可能起着关键作用。
