Hanis C L, Hewett-Emmett D, Douglas T C, Schull W J
Center for Demographic and Population Genetics, Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston 77225.
Arterioscler Thromb. 1991 Jan-Feb;11(1):123-9. doi: 10.1161/01.atv.11.1.123.
Mexican-Americans represent the single largest component of the US Hispanic population and have been shown to bear a disproportionate burden of chronic disease. A representative sample of 1,004 Mexican-Americans aged 15-74 years from Starr County, Tex., was recruited for this study. Each subject was provided a detailed physical evaluation that included measurement of fasting levels of cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol and its subfractions (HDL2 and HDL3) alpha- and beta-lipoprotein cholesterol, and low density lipoprotein cholesterol. Apolipoproteins A-I, A-II, B, C-II, C-III, and E were determined for approximately 550 of these individuals. Age- and sex-specific mean levels and percentile cut points are presented. The distributions of lipoproteins are quite similar to those of the general population except for consistently higher triglycerides in males and females and lower HDL cholesterol levels in females. These findings are consistent with the high frequency of obesity. Comparative age- and sex-specific data for the apolipoproteins are not widely available. Where such data exist, apolipoprotein levels observed in the Mexican-American population tend to be similar to or lower than the comparative data.
墨西哥裔美国人是美国西班牙裔人口中最大的单一组成部分，且已被证明承受着不成比例的慢性病负担。本研究招募了来自得克萨斯州斯塔尔县的1004名年龄在15至74岁之间的墨西哥裔美国人作为代表性样本。为每位受试者提供了详细的身体评估，包括测量胆固醇、甘油三酯、高密度脂蛋白（HDL）胆固醇及其亚组分（HDL2和HDL3）、α-和β-脂蛋白胆固醇以及低密度脂蛋白胆固醇的空腹水平。对其中约550人测定了载脂蛋白A-I、A-II、B、C-II、C-III和E。给出了年龄和性别特异性的平均水平及百分位数切点。除了男性和女性的甘油三酯水平始终较高以及女性的HDL胆固醇水平较低外，脂蛋白的分布与一般人群相当相似。这些发现与肥胖的高发生率一致。载脂蛋白的年龄和性别特异性比较数据并不广泛可得。在存在此类数据的情况下，墨西哥裔美国人群体中观察到的载脂蛋白水平往往与比较数据相似或更低。
