Masarei J R, Puddey I B, Rouse I L, Lynch W J, Vandongen R, Beilin L J
Atherosclerosis. 1986 Apr;60(1):79-87. doi: 10.1016/0021-9150(86)90090-0.
Serum levels of cholesterol, triglyceride, cholesterol in low density lipoprotein (LDL) and in high density lipoprotein (HDL) and its major subfractions, and of apolipoproteins A-I, A-II and B were measured in 48 healthy men at the end of two 6-week periods in which they consumed normal alcohol (5.0%, v/v) or low alcohol (0.9%, v/v) beer, respectively. Other dietary and behavioural variables were kept constant. Mean levels of triglyceride, HDL cholesterol, HDL2- and HDL3 cholesterol, and apolipoproteins A-I and A-II were higher at the end of the normal compared with the low alcohol periods, and levels of LDL cholesterol were lower. Body weight was greater at the end of the normal alcohol period than at the end of the period of low alcohol but multiple regression analysis suggested that the changes in lipoprotein-lipid and apolipoprotein levels were due primarily to the change in alcohol consumption rather than concomitant changes in body weight. This study confirms an effect of alcohol on both major subfractions of HDL and on its major apolipoproteins.
在48名健康男性分别饮用正常酒精含量（5.0%，v/v）或低酒精含量（0.9%，v/v）啤酒的两个6周周期结束时，测量了他们血清中的胆固醇、甘油三酯、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）及其主要亚组分中的胆固醇，以及载脂蛋白A-I、A-II和B的水平。其他饮食和行为变量保持不变。与低酒精周期结束时相比，正常酒精周期结束时甘油三酯、HDL胆固醇、HDL2和HDL3胆固醇以及载脂蛋白A-I和A-II的平均水平更高，而LDL胆固醇水平更低。正常酒精周期结束时的体重高于低酒精周期结束时，但多元回归分析表明，脂蛋白-脂质和载脂蛋白水平的变化主要归因于酒精摄入量的改变，而非体重的相应变化。本研究证实了酒精对HDL的两个主要亚组分及其主要载脂蛋白均有影响。
