利用脑损伤小鼠模型评估自噬
Evaluation of autophagy using mouse models of brain injury.
作者信息
Au Alicia K, Bayir Hülya, Kochanek Patrick M, Clark Robert S B
机构信息
Department of Critical Care Medicine, Safar Center for Resuscitation Research, Brain Trauma Research Center, and Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
出版信息
Biochim Biophys Acta. 2010 Oct;1802(10):918-23. doi: 10.1016/j.bbadis.2009.10.010. Epub 2009 Oct 30.
Autophagy is a homeostatic, carefully regulated, and dynamic process for intracellular recycling of bulk proteins, aging organelles, and lipids. Autophagy occurs in all tissues and cell types, including the brain and neurons. Alteration in the dynamics of autophagy has been observed in many diseases of the central nervous system. Disruption of autophagy for an extended period of time results in accumulation of unwanted proteins and neurodegeneration. However, the role of enhanced autophagy after acute brain injury remains undefined. Established mouse models of brain injury will be valuable in clarifying the role of autophagy after brain injury and are the topic of discussion in this review.
自噬是一种稳态的、受到精细调控的动态过程，用于细胞内大量蛋白质、老化细胞器和脂质的循环利用。自噬发生在包括脑和神经元在内的所有组织和细胞类型中。在许多中枢神经系统疾病中都观察到了自噬动态变化的改变。长时间自噬功能的破坏会导致有害蛋白质的积累和神经退行性变。然而，急性脑损伤后自噬增强的作用仍不明确。已建立的脑损伤小鼠模型对于阐明脑损伤后自噬的作用具有重要价值，也是本综述讨论的主题。
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