锝-99m-d，1-HMPAO在水溶液中对辐射分解的敏感性。
Sensitivity of technetium-99m-d,1-HMPAO to radiolysis in aqueous solutions.
作者信息
Tubergen K, Corlija M, Volkert W A, Holmes R A
机构信息
Research Service, Harry S. Truman Veterans Administration Hospital, Columbia, Missouri.
出版信息
J Nucl Med. 1991 Jan;32(1):111-5.
The sensitivity of technetium-99m- (99mTc) d,l-HMPAO to radiolytically induced dissociation in aqueous solutions was investigated. It was found that cobalt-60 (60Co) gamma irradiation of solutions containing 99mTc-d,l-HMPAO with only 1600 cGy reduced the lipophilic chelates' radiochemical purity (RCP) to 50%-60%. The radiolytic sensitivity of 99mTc-meso-HMPAO is significantly lower. The results indicate that radiolytically produced intermediates limit the in vitro stability of 99mTc-d,l-HMPAO.
研究了锝-99m（99mTc）d，l-六甲基丙二胺肟（HMPAO）在水溶液中对辐射诱导解离的敏感性。发现用仅1600 cGy的钴-60（60Co）γ射线辐照含有99mTc-d，l-HMPAO的溶液，会使亲脂性螯合物的放射化学纯度（RCP）降至50%-60%。99mTc-内消旋-HMPAO的辐射敏感性明显较低。结果表明，辐射产生的中间体限制了99mTc-d，l-HMPAO的体外稳定性。
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