Department of Anesthesiology and Pain Medicine, University of Washington Medical Center, Seattle, WA 98195, USA.
Can J Anaesth. 2009 Dec;56(12):969-81. doi: 10.1007/s12630-009-9202-y. Epub 2009 Nov 3.
The objective of this continuing professional development module is to describe the perioperative anesthesia and pain management of patients taking opioids because of chronic pain or drug addiction.
The number of patients under opioid treatment is increasing. Pain management is problematic in these patients, because regular opioid intake is associated with mechanisms of tolerance and dependence. More recently, opioid-induced hyperalgesia phenomena have been brought to light. As a rule, the usual opioid dose should be administered with the appropriate conversions, and additional requirements should be anticipated because of the surgical procedure. Local and regional anesthesia, and multimodal analgesia are indicated whenever possible. For the patient addicted to heroin or other opioids, the perioperative period is not a suitable time to initiate weaning.
The physiological and pharmacological changes caused by chronic opioid intake must be understood in order to provide optimal pain management with respect to each individual and the type of procedure.
本继续职业发展模块旨在描述因慢性疼痛或药物成瘾而服用阿片类药物的患者的围手术期麻醉和疼痛管理。
接受阿片类药物治疗的患者人数正在增加。这些患者的疼痛管理存在问题,因为常规阿片类药物的摄入与耐受和依赖的机制有关。最近,阿片类药物诱导的痛觉过敏现象已经被揭示出来。通常,应根据适当的转换给予常规阿片类药物剂量,并应预期由于手术过程而产生额外的需求。只要有可能,应采用局部和区域麻醉以及多模式镇痛。对于因海洛因或其他阿片类药物成瘾的患者,围手术期不是开始戒断的合适时机。
必须了解慢性阿片类药物摄入引起的生理和药理学变化,以便针对每个个体和手术类型提供最佳的疼痛管理。