脑磁共振磁化传递成像的体素分析在肝性脑病中的应用。
Voxel-based analyses of magnetization transfer imaging of the brain in hepatic encephalopathy.
机构信息
Institute of Radiology, University Hospital Düsseldorf, MNR Clinic, Moorenstrasse 5, Düsseldorf 40225, Germany.
出版信息
World J Gastroenterol. 2009 Nov 7;15(41):5157-64. doi: 10.3748/wjg.15.5157.
AIM
To evaluate the spatial distribution of cerebral abnormalities in cirrhotic subjects with and without hepatic encephalopathy (HE) found with magnetization transfer imaging (MTI).
METHODS
Nineteen cirrhotic patients graded from neurologically normal to HE grade 2 and 18 healthy control subjects underwent magnetic resonance imaging. They gave institutional-review-board-approved written consent. Magnetization transfer ratio (MTR) maps were generated from MTI. We tested for significant differences compared to the control group using statistical non-parametric mapping (SnPM) for a voxel-based evaluation.
RESULTS
The MTR of grey and white matter was lower in subjects with more severe HE. Changes were found in patients with cirrhosis without neurological deficits in the basal ganglia and bilateral white matter. The loss in magnetization transfer increased in severity and spatial extent in patients with overt HE. Patients with HE grade 2 showed an MTR decrease in white and grey matter: the maximum loss of magnetization transfer effect was located in the basal ganglia [SnPM (pseudo-)t = 17.98, P = 0.0001].
CONCLUSION
The distribution of MTR changes in HE points to an early involvement of basal ganglia and white matter in HE.
目的
利用磁化传递成像（MTI）评估伴有和不伴有肝性脑病（HE）的肝硬化患者脑异常的空间分布。
方法
19 名肝硬化患者按神经正常至 HE 2 级分级，18 名健康对照者接受磁共振成像检查。他们签署了机构审查委员会批准的书面同意书。从 MTI 生成磁化传递率（MTR）图。我们使用基于体素的统计非参数映射（SnPM）对 MTR 图进行了测试，以与对照组进行比较。
结果
HE 更严重的患者灰质和白质的 MTR 更低。在基底节和双侧白质中，在没有神经缺陷的肝硬化患者中发现了变化。明显 HE 患者的磁化转移损失程度和空间范围增加。HE 2 级患者的白质和灰质 MTR 降低：最大的磁化转移效应损失位于基底节[SnPM（伪）t = 17.98，P = 0.0001]。
结论
HE 中 MTR 变化的分布表明 HE 中基底节和白质的早期受累。
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