同一患者同时患有多发性骨髓瘤和皮肤间变性大T细胞淋巴瘤：二者存在因果关系吗？

Multiple myeloma and cutaneous anaplastic large T-cell lymphoma in the same patient: is there a causal relation?

作者信息

Tangour Monia, Chelly Ines, Haouet Slim, Zitouna Moncef, Kchir Nidhameddine

机构信息

Department of Pathology, Rabta Hospital, Tunis, Tunisia.

出版信息

J Cutan Pathol. 2011 Mar;38(3):298-300. doi: 10.1111/j.1600-0560.2009.01447.x.

DOI:10.1111/j.1600-0560.2009.01447.x

PMID:19891657

Abstract

Synchronous occurrence of lymphomatous proliferations of B and T lineage in the same patient is a very rare event and still poorly understood. All the cases reported in the English language literature are described as single case reports. We report a case of 49-year-old man, with 2-year history of multiple myeloma, presented with a raised, erythematous and ulcerated nodule in the anterior aspect of his right thigh. Histologic examination of biopsy specimen showed a dense dermic infiltrate made of large balastic cells displaying anaplastic morphology with no epidermotropism. Immunohistochemical study showed that tumor cells stained positive with CD30, EMA and CD4, and negative for CD3, CD8, CD5, CD20, CD79a, CD138 and anaplastic lymphoma kinase 1 (ALK or Ki-1).

摘要

同一患者同时出现B和T淋巴细胞系的淋巴瘤样增殖是非常罕见的事件，目前仍了解甚少。英文文献中报道的所有病例均为个案报告。我们报告一例49岁男性，有2年多发性骨髓瘤病史，其右大腿前侧出现一个隆起、红斑样且溃疡的结节。活检标本的组织学检查显示，由大的母细胞构成的致密真皮浸润，呈现间变形态，无亲表皮性。免疫组化研究显示，肿瘤细胞CD30、EMA和CD4染色呈阳性，而CD3、CD8、CD5、CD20、CD79a、CD138及间变性淋巴瘤激酶1（ALK或Ki-1）染色呈阴性。