Sugiura Y, Kaseda S, Kakizaki T, Takeuchi K, Iizuka Y, Nakamura N
Department of Thoracic Surgery, National Hospital Organization Kanagawa Hospital, Hadano, Japan.
Kyobu Geka. 2009 Nov;62(12):1101-4.
We experienced an extremely rare case of large cell neuroendocrine carcinoma (LCNEC) of the lung metastasizing to the tonsil. A 66-year-old woman who had been undergone radical hysterectomy and radiated on whole pelvis in June, 2006, was pointed out 2 cm diameter abnormal shadow at the right S8 of the lung by computed tomography (CT) in May, 2007. In June, 2007, the right lower lobectomy with lymphandenectomy was done by video-assisted thoracic surgery (VATS). The pathological diagnosis was stage IA LCNEC of the lung. In April, 2008, multiple metastases to the brain appeared, and the patient unederwent gamma knife treatment. In addition, metastases to the liver, lymphnode of abdomen, left adrenal and bone followed in 1 month. Although we considered a chemotherapy, her general condition deteriorated rapidly with development of right tonsil metastasis and died as lasly as 3 months later.
我们遇到了一例极为罕见的肺大细胞神经内分泌癌（LCNEC）转移至扁桃体的病例。一名66岁女性，于2006年6月接受了根治性子宫切除术并进行了全盆腔放疗，2007年5月计算机断层扫描（CT）显示其右肺S8区有一个直径2 cm的异常阴影。2007年6月，通过电视辅助胸腔镜手术（VATS）进行了右下肺叶切除术及淋巴结清扫术。病理诊断为肺部IA期LCNEC。2008年4月，出现脑多发转移，患者接受了伽玛刀治疗。此外，1个月后出现肝、腹主动脉旁淋巴结、左肾上腺及骨转移。尽管我们考虑进行化疗，但随着右扁桃体转移的出现，她的一般状况迅速恶化，最终在3个月后死亡。
