Bloch Sune Land, Sørensen Mads Sølvsten
Otopathological Laboratory, Department of Otorhinolaryngology Head and Neck Surgery, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Acta Otolaryngol. 2010 Apr;130(4):429-34. doi: 10.3109/00016480903253603.
The location and three-dimensional (3D) shapes of the otosclerotic foci suggest a general centripetal distribution of otosclerotic bone remodeling around the inner ear space, whereas the normal bone remodeling is distributed centrifugally. The existence of an inverse spatial relation between normal and otosclerotic bone remodeling suggests that inner ear mechanisms in control of bone remodeling may have a pathogenetic role in otosclerosis.
To explore the 3D shape of otosclerotic lesions around the inner ear space by introducing the use of 3D reconstructions and to discuss the results in a new context of temporal bone dynamics and perilabyrinthine signaling pathways.
Thirty-four otosclerotic lesions from 20 decalcified human temporal bones were rendered and visualized with the public 3D 'Reconstruct' software.
The majority of otosclerotic lesions were found close to the labyrinthine space at the well-established topographical sites of predilection with a smooth demarcation against the surrounding bone. However, in addition the virtual 3D technique revealed a new perilabyrinthine anisotropy of individual otosclerotic lesions, displaying a bulky end facing the inner ear space and a volumetric decline towards the capsular periphery.
耳硬化病灶的位置和三维（3D）形状表明，围绕内耳腔的耳硬化骨重塑呈向心分布，而正常骨重塑呈离心分布。正常骨重塑与耳硬化骨重塑之间存在相反的空间关系，这表明控制骨重塑的内耳机制可能在耳硬化的发病机制中起作用。
通过引入3D重建技术来探索内耳腔周围耳硬化病变的3D形状，并在颞骨动力学和迷路周围信号通路的新背景下讨论结果。
使用公共3D“重建”软件对来自20块脱钙人颞骨的34个耳硬化病变进行渲染和可视化。
大多数耳硬化病变位于迷路空间附近，处于公认的好发部位，与周围骨质界限清晰。然而，此外，虚拟3D技术还揭示了单个耳硬化病变新的迷路周围各向异性，表现为面向内耳腔的粗大末端以及朝向包膜周边的体积减小。
