左乙拉西坦抑制自由活动大鼠齿状回点燃诱导的突触增强。

Levetiracetam inhibits kindling-induced synaptic potentiation in the dentate gyrus of freely moving rats.

机构信息

Department of Psychiatry, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

出版信息

Neurosci Res. 2010 Feb;66(2):228-31. doi: 10.1016/j.neures.2009.10.014. Epub 2009 Nov 6.

DOI:10.1016/j.neures.2009.10.014

PMID:19896989

Abstract

A novel antiepileptic drug, levetiracetam, strongly suppresses the development of kindling, although the mechanisms by which it does so are still unknown. Kindling-induced synaptic potentiation (KIP) is considered to play an important role in the development of kindling. Therefore, we examined the effect of levetiracetam on KIP during perforant path kindling in freely moving rats. Daily administration of levetiracetam significantly suppressed the development of kindling. Furthermore, levetiracetam significantly inhibited the development of KIP during 21 days of kindling. These results suggest that levetiracetam may suppress kindling development through the suppression of KIP.

摘要

一种新型抗癫痫药物——左乙拉西坦，强烈抑制了点燃的发展，尽管其作用机制尚不清楚。点燃诱导的突触增强（KIP）被认为在点燃的发展中起着重要作用。因此，我们在自由活动的大鼠中检查了左乙拉西坦对海马齿状回通路点燃过程中 KIP 的影响。左乙拉西坦的每日给药显著抑制了点燃的发展。此外，左乙拉西坦在 21 天的点燃过程中显著抑制了 KIP 的发展。这些结果表明，左乙拉西坦可能通过抑制 KIP 来抑制点燃的发展。