解冻后胚胎的卵裂球数量会影响冷冻胚胎移植周期的妊娠率和分娩率。
The number of blastomeres in post-thawing embryos affects the rates of pregnancy and delivery in freeze-embryo-transfer cycles.
机构信息
Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha 410008, China.
出版信息
J Assist Reprod Genet. 2009 Nov-Dec;26(11-12):569-73. doi: 10.1007/s10815-009-9360-4. Epub 2009 Nov 7.
Abstract
PURPOSE
To observe the differences in pregnancy rates (PRs), delivery rates, and abortion rates associated with frozen-embryo-transfer (FET)-based use of post-thawing embryos with different numbers of blastomeres.
METHODS
959 FET cycles and 361 successful FET cycles performed between January 2007 and December 2007. Compare the PRs and abortion rates in post-thawing embryos with 8 blastomeres (8c), 7c, 6c, 5c, 4c,and 3c.
RESULTS
- The total PRs of post-thawing 8c, 7c, 6c, 5c, 4c, and 3c embryos were 44.1%, 41.0%, 34.4%, 23.8%, 12.5%, and 0%, respectively (p < 0.05). 2. The abortion rates for the transferred embryos of the 8c, 7c, 6c, 5c, and 4c groups were 17.92%, 19.35%, 27.69%, 24%, 20%, respectively (p < 0.05).
CONCLUSION
The number of blastomeres in the post-thawing embryos is an important factor influencing the occurrence of pregnancy in FET procedures; however, the criterion that post-thawing embryos with 50% intact blastomeres will lead to pregnancy may not be valid.
摘要
目的
观察不同卵裂球数解冻胚胎行冻融胚胎移植（FET）后妊娠率（PR）、分娩率和流产率的差异。
方法
2007 年 1 月至 2007 年 12 月间共进行了 959 个 FET 周期和 361 个成功的 FET 周期。比较解冻胚胎 8 个卵裂球（8c）、7 个卵裂球、6 个卵裂球、5 个卵裂球、4 个卵裂球和 3 个卵裂球的 PR 和流产率。
结果
- 解冻 8c、7c、6c、5c、4c 和 3c 胚胎的总 PR 分别为 44.1%、41.0%、34.4%、23.8%、12.5%和 0%（p < 0.05）。2. 8c、7c、6c、5c 和 4c 组移植胚胎的流产率分别为 17.92%、19.35%、27.69%、24%、20%（p < 0.05）。
结论
解冻胚胎的卵裂球数是影响 FET 妊娠的重要因素；然而，解冻后有 50%卵裂球完整的胚胎将导致妊娠的标准可能并不成立。
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