The Scripps-Oxford Laboratory, Department of Biochemistry, University of Oxford, South Parks Rd., Oxford OX13QU, UK.
Angew Chem Int Ed Engl. 2009;48(50):9469-72. doi: 10.1002/anie.200904524.
[Image: see text] Cholesterol sterol aldehydes inhibit the misfolding of a prion protein fragment that induces GSS in mice. Atheronal-B completely inhibits the α to β-form transformation of MoPrP(89-143, P101L) a mechanism that involves adduction to the protein. This result offers a paradigm shift in lipid aldehyde induced protein misfolding and offers a new molecular scaffold on which to develop new potential prion disease therapeutics
胆固醇甾醇醛抑制诱导 GSS 的朊病毒蛋白片段的错误折叠。Atheronal-B 完全抑制 MoPrP(89-143, P101L) 的α到β形式的转变,该机制涉及与蛋白质的加成。这一结果提供了脂质醛诱导的蛋白质错误折叠的范例转变,并提供了一个新的分子支架,在此基础上可以开发新的潜在朊病毒疾病治疗方法。