Menczer J, Schreiber L, Kravtsov V, Berger E, Golan A, Levy T
Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, E. Wolfson Medical Center, Holon, Israel.
Eur J Gynaecol Oncol. 2009;30(5):531-5.
The aim of the study was to assess whether COX-2 expression in epithelial ovarian carcinoma (EOC) tissue can distinguish between platin-sensitive and platin-resistant tumors.
Clinical and histological data were obtained from medical records of EOC patients diagnosed between the years 1995 and 2005. Patients in complete clinical remission for > 6 months after discontinuation of first-line chemotherapy were considered to be platin-sensitive. Survival of < or = 2 and > 5 years after diagnosis was considered as short- and long-term survival, respectively. Immunohistochemistry staining was performed on deparaffinized sections of tissue blocks obtained at first surgery. The intensity of staining and the percentage of stained cells was assessed by two pathologists blinded to clinical data and a scoring index was calculated.
Among 79 patients a positive stain (> 10% of cells stained) was observed in 61 (77.2%). No statistically significant association between distribution of platin sensitivity and immunohistochemical COX-2 staining parameters was observed, although the rate of long-term survival was significantly higher among platin-sensitive then among platin-resistant/unresponsive patients.
Immunohistochemically determined COX-2 expression in EOC is not associated with platin sensitivity and survival.
本研究旨在评估上皮性卵巢癌（EOC）组织中COX-2的表达是否能够区分铂类敏感和铂类耐药肿瘤。
临床和组织学数据取自1995年至2005年间确诊的EOC患者的病历。一线化疗停药后临床完全缓解超过6个月的患者被视为铂类敏感。诊断后生存时间≤2年和>5年分别被视为短期和长期生存。对首次手术获取的组织块石蜡切片进行免疫组织化学染色。由两名对临床数据不知情的病理学家评估染色强度和染色细胞百分比，并计算评分指数。
79例患者中，61例（77.2%）观察到阳性染色（>10%的细胞染色）。尽管铂类敏感患者的长期生存率显著高于铂类耐药/无反应患者，但未观察到铂类敏感性分布与免疫组织化学COX-2染色参数之间存在统计学显著关联。
免疫组织化学测定的EOC中COX-2表达与铂类敏感性和生存无关。
