Soga Jun
Nihon Rinsho. 2009 Nov;67(11):2201-6.
Since Siegfried Oberndorfer proposed the term "carcinoid" in 1907, over 100 years have passed. In 1876, he was born at Munich and, in 1907 reported a series of 6 cases of "carcinoids" in the small intestine as benign tumorlets. In 1929, he partly revised his initial concept of carcinoid, pointing out some cases being malignant with metastases. In 1944, he demised with a thymoma. A proposal of the concept of GEP system in 1973 was followed by proposals of the concept of neuroendocrine tumor (NET) and the GEP-NET classification based on the WHO histological classification, later developing into the TNM classification by the ENETS (European NET Society), which was founded in 2004. Carcinoids are now included in a corner of the GEP-NET classification with a somewhat confusing expression of "benign biological(clinical) behavior" vs. histological malignancy.
自1907年西格弗里德·奥本多夫提出“类癌”一词以来,已经过去了100多年。1876年,他出生于慕尼黑,1907年报告了一系列6例小肠“类癌”,将其视为良性微小肿瘤。1929年,他对类癌的最初概念进行了部分修正,指出有些病例是恶性且有转移的。1944年,他因胸腺瘤去世。1973年提出GEP系统概念后,又相继提出了神经内分泌肿瘤(NET)概念以及基于世界卫生组织组织学分类的GEP-NET分类,后来发展为2004年成立的欧洲神经内分泌肿瘤协会(ENETS)的TNM分类。如今,类癌被纳入GEP-NET分类的一个范畴,其“良性生物学(临床)行为”与组织学恶性之间的表述有些令人困惑。