de Zeeuw Sharonne, Wildenberg Frits, Strobbe Luc, Wobbes Theo
Radboud Universitair Medisch Centrum, afdeling Chirurgie, The Netherlands.
Ned Tijdschr Geneeskd. 2009;153:A56.
To establish the frequency of re-excision or mastectomy in women who had breast-conserving treatment for invasive lobular mammary carcinoma.
Retrospective.
Data on the number of patients with invasive carcinoma from 1998-2006 were obtained from the national pathology database (PALGA) and the Dutch Comprehensive Cancer Centre East. The following data on patients who had undergone breast-conserving treatment for invasive lobular carcinoma were collected from the electronic patient records: age, localization procedure with wire-localisation and tumour size.
The frequency of re-excision or mastectomy following initial breast-conserving surgery in 123 patients with invasive lobular carcinoma was 46.3 % versus 31.5 % in 877 patients with other types of invasive carcinoma. The number of re-excisions was higher in the group with invasive non-lobular carcinoma (4.9% versus 9.2%), and the number of conversions to mastectomy was higher in the group with invasive lobular carcinoma (41.5% versus 20.1%). The age of the patient, the localisation procedure and tumour size were not significant predictors of a tumour-free surgical margin or for the necessity of re-excision.
The frequency of re-excision in patients with invasive lobular carcinoma was higher than in patients with other types of breast cancer. There was no statistically significant predictor for obtaining a tumour-free surgical margin.
确定接受保乳治疗的浸润性小叶乳腺癌女性患者再次切除或乳房切除术的发生率。
回顾性研究。
从国家病理数据库（PALGA）和荷兰东部综合癌症中心获取1998年至2006年浸润性癌患者的数据。从电子病历中收集以下接受浸润性小叶癌保乳治疗患者的数据：年龄、带线定位的定位手术及肿瘤大小。
123例浸润性小叶癌患者初次保乳手术后再次切除或乳房切除术的发生率为46.3%，而877例其他类型浸润性癌患者为31.5%。浸润性非小叶癌组再次切除的数量更高（4.9%对9.2%），浸润性小叶癌组转为乳房切除术的数量更高（41.5%对20.1%）。患者年龄、定位手术和肿瘤大小并非无瘤手术切缘或再次切除必要性的显著预测因素。
浸润性小叶癌患者再次切除的发生率高于其他类型乳腺癌患者。对于获得无瘤手术切缘，没有统计学上显著的预测因素。
