van Haelst Ingrid M M, Bocxe J Suzanne T H, Burger Bart J, Doodeman H Jeroen J, de Roode Eric C G, van Genderen Wilco E
Medisch Centrum Alkmaar, discipline Ziekenhuisapotheek, Alkmaar, The Netherlands.
Ned Tijdschr Geneeskd. 2009;153:B428.
To gain insight into the outcomes of postoperative pain treatment using patient-controlled intravenous analgesia (PCIA) with morphine and oral analgesics after total hip or knee arthroplasty (THA or TKA).
Prospective observational study.
In 2006-2007, 154 THA and 110 TKA patients who underwent arthroplasty at the Medical Centre Alkmaar were included in this study. Postoperative pain treatment consisted of a PCIA pump with morphine and oral analgesics. Primary endpoints were effectiveness of pain treatment and the incidence of side effects.
After THA, 65% of the patients had an acceptable pain score at rest on the day of surgery (day 0), increasing to >95% from 2 days after the operation onwards. On day 1, 43% had an acceptable pain score during movement, increasing to >90% from day 2 onwards. On day 0, nausea occurred in 24% and vomiting in 25% of patients; on day 1, these figures were 21% and 29% respectively. After TKA, 45% of the patients had acceptable pain at rest on day 0, increasing to >or=95% from day 3 onwards. On day 1, pain during movement was acceptable in 24% of the patients, increasing to 80% on day 4. On day 0 following TKA nausea occurred in 37% and vomiting in 39% of patients; on day 1, these figures were 26% and 23%, respectively.
In view of the somewhat disappointing effectiveness and the side effects of a PCIA pump with morphine and oral analgesics, adjustments in the treatment of pain following THA and TKA are required. The greatest improvement can be realised on the day of surgery and the first postoperative day.
深入了解全髋关节或全膝关节置换术(THA或TKA)后使用吗啡患者自控静脉镇痛(PCIA)和口服镇痛药进行术后疼痛治疗的效果。
前瞻性观察研究。
2006年至2007年,阿尔克马尔医疗中心154例行THA和110例行TKA的关节置换术患者纳入本研究。术后疼痛治疗包括使用含吗啡的PCIA泵和口服镇痛药。主要终点是疼痛治疗的有效性和副作用发生率。
THA后,65%的患者在手术当天(第0天)静息时疼痛评分可接受,术后2天起升至>95%。第1天,43%的患者活动时疼痛评分可接受,术后2天起升至>90%。第0天,24%的患者出现恶心,25%的患者出现呕吐;第1天,这些数字分别为21%和29%。TKA后,45%的患者在第0天静息时疼痛可接受,术后3天起升至≥95%。第1天,24%的患者活动时疼痛可接受,第4天升至80%。TKA术后第0天,37%的患者出现恶心,39%的患者出现呕吐;第1天,这些数字分别为26%和23%。
鉴于含吗啡的PCIA泵联合口服镇痛药的疗效略显令人失望且存在副作用,THA和TKA术后疼痛治疗需要调整。手术当天和术后第一天改善最为明显。