Department of Neurology, Unit Neuropsychology, University Medical Center Groningen, the Netherlands.
J Int Neuropsychol Soc. 2010 Jan;16(1):118-29. doi: 10.1017/S1355617709991020. Epub 2009 Nov 10.
A multicenter randomized control trial (RCT) was conducted to evaluate the effects of a treatment for dysexecutive problems after acquired brain injury (ABI) on daily life functioning. Seventy-five ABI patients were randomly allocated to either the experimental treatment, multifaceted strategy training for executive dysfunction, or a control treatment, computerized cognitive function training. Assessment took place before, directly after, and 6 months post-treatment. The primary outcome measure, the Role Resumption List (RRL), and two other follow-up measures, the Treatment Goal Attainment (TGA) and the Executive Secretarial Task (EST), were indications of daily life executive functioning. The experimental group improved significantly more over time than the controls on the RRL and attained significantly higher scores on the TGA and EST. We conclude that our treatment has resulted in significant improvements of executive functioning in daily life, lasting at least 6 months post-treatment. Although control patients' satisfaction and subjective well-being were at the same level, the experimental group had better abilities to set and accomplish realistic goals, to plan, initiate, and regulate a series of real-life tasks, and to resume previous roles with respect to work, social relations, leisure activities, and mobility.
一项多中心随机对照试验（RCT）评估了一种针对后天性脑损伤（ABI）后执行功能障碍的治疗方法对日常生活功能的影响。75 名 ABI 患者被随机分配到实验组（执行功能障碍的多方面策略训练）或对照组（计算机认知功能训练）。评估在治疗前、治疗后直接和治疗后 6 个月进行。主要结局指标是角色恢复清单（RRL），另外两个随访指标是治疗目标达成（TGA）和执行秘书任务（EST），这些指标表明了日常生活中的执行功能。实验组在 RRL 上的改善明显优于对照组，并且在 TGA 和 EST 上的得分也明显更高。我们得出结论，我们的治疗在日常生活中导致了执行功能的显著改善，至少在治疗后 6 个月内持续存在。尽管对照组患者的满意度和主观幸福感处于同一水平，但实验组在设定和实现现实目标、规划、启动和调节一系列现实生活任务以及恢复以前的工作、社会关系、休闲活动和流动性方面的能力更强。
