人冠状动脉粥样硬化斑块中调节性CD4+CD25+foxp3+细胞标志物的表达。
Expression of markers of regulatory CD4+CD25+foxp3+ cells in atherosclerotic plaques of human coronary arteries.
作者信息
Sokolov V O, Krasnikova T L, Prokofieva L V, Kukhtina N B, Arefieva T I
机构信息
Russian Cardiology Research-and-Production Complex, Russian Medical Technologies, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2009 Jun;147(6):726-9. doi: 10.1007/s10517-009-0595-y.
The content of marker foxp3 of regulatory T cells and chemokines in atherosclerotic plaques of human coronary arteries was measured by the polymerase chain reaction. In vitro migration of regulatory CD4(+)CD25(+)foxp3(+) cells in the CD4(+) lymphocyte population from healthy donors was studied after treatment with chemokines I-309, IP-10, and SDF-1. mRNA for the factor foxp3 and chemokines SDF-1, I-309, and MIP-1beta were found in the majority of samples from atherosclerotic plaques. SDF-1 induced maximum migratory response of CD4(+)CD25(+)foxp3(+) cells.
采用聚合酶链反应检测人冠状动脉粥样硬化斑块中调节性T细胞标志物foxp3及趋化因子的含量。在用趋化因子I-309、IP-10和SDF-1处理后，研究了健康供体CD4(+)淋巴细胞群体中调节性CD4(+)CD25(+)foxp3(+)细胞的体外迁移。在大多数动脉粥样硬化斑块样本中发现了foxp3因子及趋化因子SDF-1、I-309和MIP-1β的mRNA。SDF-1诱导CD4(+)CD25(+)foxp3(+)细胞产生最大迁移反应。
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