Tonevitsky E A, Trushkin E V, Shkurnikov M U, Akimov E B, Sakharov D A
All-Russian Institute of Physical Culture and Athletics, Moscow, Russia.
Bull Exp Biol Med. 2009 Jun;147(6):733-6. doi: 10.1007/s10517-009-0593-0.
Intensive exercise triggers the cascade processes of body adaptation, including modulation of splisosome functioning, and can lead to modification of its activity and choice of alternative exons. We studied the effect of exercise of the maximum aerobic power on activation of transcription of genes involved in the splicing process. Short-term exercise resulted in a significant increase of mRNA expression of genes encoding proteins involved in the formation of precatalytic splisosome: DDX17, DDX46, HNRNPR, PRPF4B, and SRPK2. The role of the detected regulators in initiation of splisosome assembly under conditions of maximally intensive exercise is discussed.
高强度运动触发身体适应的级联过程，包括剪接体功能的调节，并可能导致其活性的改变和可变外显子的选择。我们研究了最大有氧功率运动对参与剪接过程的基因转录激活的影响。短期运动导致参与前催化剪接体形成的蛋白质编码基因的mRNA表达显著增加：DDX17、DDX46、HNRNPR、PRPF4B和SRPK2。讨论了在最大强度运动条件下检测到的调节因子在剪接体组装起始中的作用。
