印度南部结核分枝杆菌特异性抗原培养滤液蛋白-10 的细胞免疫反应。
Cellular immune response to Mycobacterium tuberculosis-specific antigen culture filtrate protein-10 in south India.
机构信息
Department of Immunology, Tuberculosis Research Centre (ICMR), Chennai, India.
出版信息
Med Microbiol Immunol. 2010 Feb;199(1):11-25. doi: 10.1007/s00430-009-0129-2. Epub 2009 Nov 10.
The Mycobacterium tuberculosis (M. tuberculosis)-specific culture filtrate protein-10 (CFP-10) is highly recognized by M. tuberculosis infected subjects. In the present study, the proliferative response and IFN-gamma secretion was found for C-terminal peptides of the protein (Cfp6(51-70), Cfp7(61-80), Cfp8(71-90), and Cfp9(81-100)). The alleles HLA DRB1 *04 and HLA DRB1 *10 recognized the C-terminal peptides Cfp7, Cfp8, and Cfp9 in HHC. Cfp6 was predominantly recognized by the alleles HLA DRB1 *03 and HLA DRB1 *15 by PTB. The minimal nonameric epitopes from the C-terminal region were CFP-10(56-64) and CFP-10(76-84). These two peptides deserve attention for inclusion in a vaccine against tuberculosis in this region.
结核分枝杆菌（M. tuberculosis）特异性培养滤液蛋白 10（CFP-10）在结核分枝杆菌感染的患者中受到高度认可。在本研究中，发现了该蛋白的 C 末端肽（Cfp6（51-70）、Cfp7（61-80）、Cfp8（71-90）和 Cfp9（81-100））的增殖反应和 IFN-γ分泌。等位基因 HLA DRB1 * 04 和 HLA DRB1 * 10 识别 HHC 中的 C 末端肽 Cfp7、Cfp8 和 Cfp9。Cfp6 主要被等位基因 HLA DRB1 * 03 和 HLA DRB1 * 15 识别。来自 C 末端区域的最小非九肽表位是 CFP-10（56-64）和 CFP-10（76-84）。这两个肽值得关注，因为它们可能包含在针对该区域的结核病疫苗中。
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