Department of Obstetrics and Gynaecology, Conception Hospital, Marseille, France.
Ultrasound Obstet Gynecol. 2009 Dec;34(6):715-9. doi: 10.1002/uog.7344.
To compare sonographic characteristics of the endometrium and follicles during in-vitro fertilization (IVF) before and after methotrexate (MTX) treatment for ectopic pregnancy.
This retrospective study, conducted at Conception Hospital from January 2000 to July 2007, included all patients diagnosed with an ectopic pregnancy resulting from IVF treatment that was treated with MTX and who then underwent another IVF cycle. We compared the number and size of follicles and the endometrial thickness and quality on the day of human chorionic gonadotropin injection in the cycles before and after the MTX treatment to determine whether MTX had any effect.
Eleven patients were included in the study. The median interval between the IVF cycle resulting in ectopic pregnancy and the first IVF cycle after MTX therapy was 180 (range, 150-900) days. There was no statistically significant difference between the before and after MTX treatment groups with respect to number of follicles (14 (3-20) vs. 9 (4-16), P = 0.12), follicle size (16.5 (14.7-21.7) mm vs. 17.8 (14.9-19.8) mm, P = 0.37), endometrial thickness (10.0 (9.5-12.0) mm vs. 10.0 (7.5-14.0) mm, P = 0.31) or endometrial quality (P = 0.32). Four women became pregnant during the IVF cycle following MTX treatment.
Ultrasound monitoring showed no modification of the characteristics of the endometrium or follicles during IVF after MTX treatment for ectopic pregnancy.
比较异位妊娠接受氨甲喋呤（MTX）治疗前后体外受精（IVF）过程中子宫内膜和卵泡的超声特征。
本回顾性研究于 2000 年 1 月至 2007 年 7 月在 Conception 医院进行，纳入所有因接受 IVF 治疗而发生异位妊娠并接受 MTX 治疗的患者，且这些患者随后又进行了另一次 IVF 周期。我们比较了 MTX 治疗前后人绒毛膜促性腺激素（hCG）注射日的卵泡数量和大小、子宫内膜厚度和质量，以确定 MTX 是否有任何影响。
该研究纳入了 11 例患者。发生异位妊娠的 IVF 周期与接受 MTX 治疗后的首次 IVF 周期之间的中位间隔时间为 180（范围，150-900）天。MTX 治疗前后组在卵泡数量（14（3-20）vs. 9（4-16），P=0.12）、卵泡大小（16.5（14.7-21.7）mm vs. 17.8（14.9-19.8）mm，P=0.37）、子宫内膜厚度（10.0（9.5-12.0）mm vs. 10.0（7.5-14.0）mm，P=0.31）或子宫内膜质量（P=0.32）方面均无统计学差异。4 例女性在 MTX 治疗后的 IVF 周期中怀孕。
超声监测显示，异位妊娠接受 MTX 治疗后，IVF 过程中子宫内膜和卵泡的特征没有改变。
