Cohen Jerome D
Department of Internal Medicine (Cardiology), St. Louis University School of Medicine, USA.
Manag Care. 2009 Oct;18(10):51-8.
Hypertension (HTN) continues to be a serious public health problem in the United States and is a major risk factor for stroke, heart failure, myocardial infarction, and other serious cardiovascular and renal diseases. Because HTN can be asymptomatic, its detection and control continues to be a challenge. The total economic burden of HTN is estimated at $73.4 billion in 2009.
To examine the potential prognostic utility of biomarkers to assess hypertension-related cardiovascular risk and their potential impact on treatment in the context of current epidemiology and demographics of HTN.
Although blood pressure control rates among people treated for HTN have increased from 51.3 percent to 63.9 percent over the past five years, there remains a vast unmet need for improved efficiency and effectiveness in diagnosis and treatment. Biomarkers provide a promising approach to improve detection and management of disease progression while optimizing health care expenditures.
在美国,高血压仍然是一个严重的公共卫生问题,并且是中风、心力衰竭、心肌梗死以及其他严重心血管和肾脏疾病的主要危险因素。由于高血压可能没有症状,其检测和控制仍然是一项挑战。2009年高血压的总经济负担估计为734亿美元。
在当前高血压的流行病学和人口统计学背景下,研究生物标志物评估高血压相关心血管风险的潜在预后效用及其对治疗的潜在影响。
尽管在过去五年中接受高血压治疗的人群血压控制率已从51.3%提高到63.9%,但在提高诊断和治疗的效率和效果方面仍有大量未满足的需求。生物标志物为改善疾病进展的检测和管理同时优化医疗保健支出提供了一种有前景的方法。