Williams Michael D, Omran M Louay, Gordon Glenn L
Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, USA.
Mo Med. 2009 Sep-Oct;106(5):356-60.
Crohn's disease is a complex disease process causing transmural inflammation of the gastrointestinal tract, which produces a constellation of symptoms including abdominal pain, frequent loose stools, fistula formation, and extraintestinal manifestations. Biologic therapy, including tumor necrosis factor alpha inhibitors, are a growing class of agents, which have demonstrated efficacy in the treatment of moderate to severe Crohn's disease. Their indications for use have grown, as has the understanding of their associated safety concerns.
克罗恩病是一种导致胃肠道透壁性炎症的复杂疾病过程，会产生一系列症状，包括腹痛、频繁腹泻、瘘管形成以及肠外表现。生物疗法，包括肿瘤坏死因子α抑制剂，是一类不断发展的药物，已证明在治疗中度至重度克罗恩病方面有效。它们的使用指征不断增加，对其相关安全问题的认识也在提高。
