Division of Endocrinology and Diabetes, Department of Internal Medicine, Kantonsspital St. Gallen, Rorschacherstrasse 95, 9007 St. Gallen, Switzerland.
Gynecol Endocrinol. 2009 May;25(5):324-7. doi: 10.1080/09513590902730788.
Recent onset of hirsutism in postmenopausal women is mostly caused by androgen secretion from adrenal or ovarian tumours. Ovarian hyperthecosis (OH) is a cause of hyperandrogenism in premenopausal women, few cases of postmenopausal presentation have been described. We report on a 73-year old women with androgenic alopecia and hirsutism of recent onset because of elevated testosterone levels. Radiologic imaging showed no tumours of the adrenal glands and ovaries. Careful re-evaluation revealed increased ovarian size in relation to age. Bilateral ovarectomy confirmed the diagnosis of ovarian hyerthecosis and led to improvement of clinical findings. It is important to review imaging findings as OH may elude imaging studies. OH should be included in the differential diagnosis of postmenopausal hyperadnrogenism particularly if androgen excess is of recent-onset.
近期发生的绝经后妇女多毛症主要是由肾上腺或卵巢肿瘤分泌雄激素引起的。卵巢性细胞增生症（OH）是绝经前妇女高雄激素血症的一个原因，绝经后表现的病例很少有描述。我们报告了一例 73 岁的妇女，她因睾酮水平升高而出现雄激素性脱发和近期发生的多毛症。影像学检查未发现肾上腺和卵巢肿瘤。仔细重新评估显示卵巢大小与年龄有关而增大。双侧卵巢切除术证实了卵巢性细胞增生症的诊断，并使临床发现得到改善。重要的是要重新评估影像学检查结果，因为 OH 可能逃避影像学研究。OH 应纳入绝经后高雄激素血症的鉴别诊断，特别是如果雄激素过多是近期发生的。
