Department of Obstetrics and Gynecology, University of Pisa, via Roma 35, 56100 Pisa, Italy.
Gynecol Endocrinol. 2009 May;25(5):335-43. doi: 10.1080/09513590802630146.
The prevalence of the metabolic syndrome (MBS) abnormalities in Italian adolescents with polycystic ovary syndrome (PCOS) was evaluated.
Retrospective chart review.
University outpatient clinic.
Fifty-three adolescents with PCOS.
Subjects underwent a physical evaluation. Fasting blood samples were taken for the evaluation of metabolic parameters.
The prevalence of MBS abnormalities according to de Ferranti criteria was assessed.
9.4% of adolescents with PCOS had the MBS (three abnormalities). Twelve girls (22.7%) had two abnormalities. Seventeen (32.1%) of PCOS girls have no MBS abnormalities. PCOS adolescents with the MBS were more obese, insulin resistant and they had significantly higher levels of total and free testosterone. The number of metabolic abnormalities correlated with free, total testosterone, free androgen index (FAI) and body mass index (BMI). Groups with two or three abnormalities were not differentiated by BMI, insulin, lipids, blood pressure, but they were differentiated by total and free testosterone and FAI. Adolescents with the MBS have higher total and free testosterone and FAI than girls with two MBS abnormalities.
The MBS and its components are present in some adolescents with PCOS, placing them at increased risk for cardiovascular disease early in adulthood. Hyperandrogenemia is a risk factor for MBS independent of obesity.
评估意大利多囊卵巢综合征（PCOS）青少年代谢综合征（MBS）异常的流行情况。
回顾性病历审查。
大学门诊诊所。
53 名患有 PCOS 的青少年。
对受试者进行身体评估。采集空腹血样以评估代谢参数。
根据 de Ferranti 标准评估 MBS 异常的发生率。
9.4%的 PCOS 青少年存在 MBS（三种异常）。12 名女孩（22.7%）有两种异常。17 名（32.1%）PCOS 女孩没有 MBS 异常。患有 MBS 的 PCOS 青少年更肥胖、胰岛素抵抗，总睾酮和游离睾酮水平显著更高。代谢异常的数量与游离睾酮、总睾酮、游离雄激素指数（FAI）和体重指数（BMI）相关。有两种或三种异常的组不能通过 BMI、胰岛素、血脂、血压来区分，但可以通过总睾酮、游离睾酮和 FAI 来区分。患有 MBS 的青少年的总睾酮和游离睾酮以及 FAI 高于有两种 MBS 异常的女孩。
MBS 及其成分存在于一些患有 PCOS 的青少年中，使他们在成年早期患心血管疾病的风险增加。高雄激素血症是 MBS 的一个独立于肥胖的危险因素。
