Carmina E, Napoli N, Longo R A, Rini G B, Lobo R A
Department of Clinical Medicine, University of Palermo, Palermo, Italy.
Eur J Endocrinol. 2006 Jan;154(1):141-5. doi: 10.1530/eje.1.02058.
Metabolic syndrome (MBS) is a common disorder and is thought to be extremely prevalent in polycystic ovary syndrome (PCOS). In the USA the prevalence of MBS in PCOS has been reported to be as high as 43-46% using Adult Treatment Panel III (ATP-III) criteria. Because of differences in diet, lifestyle and genetic factors, we postulated that the prevalence of MBS might not be as high in Italian women. This study sought to determine the prevalence of MBS in Italian women using both the ATP-III and the World Health Organization (WHO) criteria and to determine whether the prevalence is influenced by the way in which PCOS is diagnosed.
Assessment of the prevalence of MBS in 282 women with PCOS, aged 18-40 years, living in western Sicily. Eighty-five age- and weight-matched normal women served as controls.
Patients were divided into those with chronic anovulation and hyperandrogenism (classic PCOS; n = 225) and others with hyperandrogenism and polycystic ovaries but who were ovulatory (ovulatory PCOS; n = 57). A 75 g oral glucose tolerance test was carried out, as were lipid determinations; insulin resistance was assessed by the Quantitative Insulin-Sensitivity Check Index (QUICKI). We used ATP-III and WHO criteria to diagnose MBS.
Using ATP-III criteria, the prevalence of MBS was 8.2% and using WHO criteria it was 16% in Italian women with PCOS. In controls, the prevalence was 2.4% using both methods. In classic PCOS patients, MBS was higher (8.9% by ATP-III, 17.3% by WHO) than in ovulatory PCOS (5% and 10.6% respectively). Body weight significantly modified prevalence rates.
MBS is substantially higher in women with PCOS than in the general population, and the prevalence is higher in those women diagnosed by classic criteria. However, the prevalence of MBS in PCOS appears to be much lower in Italy than in the USA.
代谢综合征（MBS）是一种常见疾病，被认为在多囊卵巢综合征（PCOS）中极为普遍。在美国，根据成人治疗小组第三次报告（ATP-III）标准，PCOS中MBS的患病率据报道高达43%-46%。由于饮食、生活方式和遗传因素的差异，我们推测意大利女性中MBS的患病率可能没那么高。本研究旨在使用ATP-III和世界卫生组织（WHO）标准确定意大利女性中MBS的患病率，并确定患病率是否受PCOS诊断方式的影响。
对居住在西西里岛西部的282名年龄在18至40岁的PCOS女性进行MBS患病率评估。85名年龄和体重匹配的正常女性作为对照。
患者分为慢性无排卵和高雄激素血症患者（经典型PCOS；n = 225）以及高雄激素血症和多囊卵巢但有排卵的患者（排卵型PCOS；n = 57）。进行了75克口服葡萄糖耐量试验以及血脂测定；通过定量胰岛素敏感性检查指数（QUICKI）评估胰岛素抵抗。我们使用ATP-III和WHO标准诊断MBS。
根据ATP-III标准，意大利PCOS女性中MBS的患病率为8.2%，根据WHO标准为16%。在对照组中，两种方法得出的患病率均为2.
