在南卡罗来纳州参加医疗补助保险的女性中，性传播感染与早产风险增加有关。
Sexually transmitted infection is associated with increased risk of preterm birth in South Carolina women insured by Medicaid.
作者信息
Mann Joshua R, McDermott Suzanne, Gill Tariq
机构信息
Department of Family and Preventive Medicine, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
出版信息
J Matern Fetal Neonatal Med. 2010 Jun;23(6):563-8. doi: 10.3109/14767050903214574.
OBJECTIVE
We investigated the association between diagnosed maternal sexually transmitted infections (STIs) and very preterm or late preterm birth in 108,346 South Carolina women receiving medical care purchased by Medicaid from 1996 through 2002, and delivering singleton infants.
METHODS
ICD9 codes in South Carolina Medicaid data were used to identify maternal infections. Gestational age was obtained from birth certificates.
RESULTS
Trichomoniasis, gonorrhea, and/or Chlamydia/non-gonococcal urethritis (NGU) were diagnosed in 4,208 women. Preterm birth occurred in just over 9% of pregnancies. Women diagnosed with one of the infections in the first 7 months of pregnancy were significantly more likely to deliver very preterm infants (adjusted HR = 1.73, p < 0.0001). Women with infection in the first 8 months were significantly more likely to deliver between 33 and 36 weeks (adjusted HR = 1.39, p < 0.0001). Of the three infections, Chlamydia/NGU was most strongly associated with preterm birth and infections occurring later in pregnancy (months 6, 7, and 8).
CONCLUSION
STIs appear to be preventable risk factors for very and late preterm birth.
目的
我们调查了1996年至2002年期间接受医疗补助购买医疗服务、分娩单胎婴儿的108,346名南卡罗来纳州女性中，确诊的孕产妇性传播感染（STIs）与极早产或晚期早产之间的关联。
方法
使用南卡罗来纳州医疗补助数据中的ICD9编码来识别孕产妇感染情况。孕周从出生证明中获取。
结果
4,208名女性被诊断出患有滴虫病、淋病和/或衣原体/非淋菌性尿道炎（NGU）。超过9%的妊娠发生早产。在妊娠前7个月被诊断出感染其中一种疾病的女性，分娩极早产婴儿的可能性显著更高（校正风险比=1.73，p<0.0001）。在妊娠前8个月感染的女性，在33至36周之间分娩的可能性显著更高（校正风险比=1.39，p<0.0001）。在这三种感染中，衣原体/NGU与早产以及妊娠后期（第6、7和8个月）发生的感染关联最为密切。
结论
性传播感染似乎是极早产和晚期早产的可预防风险因素。
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