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机器人辅助根治性膀胱切除术:平均随访 25 个月的中期生存结果。

Robot-assisted radical cystectomy: intermediate survival results at a mean follow-up of 25 months.

机构信息

Department of Urology, Mayo Clinic, Phoenix, AZ, USA.

出版信息

BJU Int. 2010 Jun;105(12):1706-9. doi: 10.1111/j.1464-410X.2009.09042.x. Epub 2009 Nov 9.

Abstract

OBJECTIVE

To assess the overall and disease-specific survival rates of patients undergoing robot-assisted radical cystectomy (RARC) compared with historical open cystectomy.

PATIENTS AND METHODS

Survival, pathological and demographic data were collected on all patients undergoing RARC for bladder cancer from both Tulane University Medical Center and Mayo Clinic Arizona. Of a total of 80 RARCs we only included those with a follow-up of > or =6 months from surgery. Survival curves were compared with those from historical series of open cystectomy.

RESULTS

Of the 80 patients 59 were identified as having a follow-up of > or =6 months from the date of surgery. The mean (range) follow-up was 25 (6-49) months. Overall survival rates at 12 and 36 months were 82% and 69%, respectively, and disease-specific survival rates were 82% and 72% at 12 and 36 months, respectively. These results are comparable to survival rates from open cystectomy. As expected, patients with lymph node-positive disease fared worse than those with lymph node-negative disease. Patients with extravesical lymph node-negative disease (pT3, pT4) fared worse than patients with organ-confined lymph node-negative disease. Also, patients with lymph node-positive disease fared worse than those with extravesical lymph node-negative disease, which is consistent with historical results of open cystectomy.

CONCLUSIONS

RARC has a comparable survival rate to open cystectomy in the intermediate follow-up. Further study with a longer follow-up and more patients is necessary to determine any long-term survival benefits.

摘要

目的

评估与历史上的开放性膀胱切除术相比,接受机器人辅助根治性膀胱切除术(RARC)的患者的总体生存率和疾病特异性生存率。

患者和方法

从杜兰大学医学中心和亚利桑那州梅奥诊所收集了所有接受膀胱癌 RARC 的患者的生存、病理和人口统计学数据。在总共 80 例 RARC 中,我们仅纳入了手术随访时间>或=6 个月的患者。生存曲线与历史上的开放性膀胱切除术系列进行了比较。

结果

80 例患者中,有 59 例患者的随访时间>或=手术日期后 6 个月。平均(范围)随访时间为 25(6-49)个月。12 个月和 36 个月的总生存率分别为 82%和 69%,12 个月和 36 个月的疾病特异性生存率分别为 82%和 72%。这些结果与开放性膀胱切除术的生存率相当。正如预期的那样,淋巴结阳性疾病患者的预后比淋巴结阴性疾病患者差。外生淋巴结阴性疾病(pT3、pT4)患者的预后比器官局限性淋巴结阴性疾病患者差。此外,淋巴结阳性疾病患者的预后比外生淋巴结阴性疾病患者差,这与开放性膀胱切除术的历史结果一致。

结论

在中期随访中,RARC 的生存率与开放性膀胱切除术相当。需要进一步进行长期随访和纳入更多患者的研究,以确定是否存在长期生存获益。

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