胃酸分泌过多状态：最新见解与进展
Gastric acid hypersecretory states: recent insights and advances.
作者信息
Osefo Nauramy, Ito Tetsuhide, Jensen Robert T
机构信息
Digestive Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9C-103, Bethesda, MD 20892, USA.
出版信息
Curr Gastroenterol Rep. 2009 Dec;11(6):433-41. doi: 10.1007/s11894-009-0067-6.
Abstract
Gastric acid hypersecretory states are characterized by basal hypersecretion of gastric acid and historically include disorders associated with hypergastrinemia, hyperhistaminemia, and those of unknown etiology. Although gastric acid secretion is infrequently measured, it is important to recognize the role of gastric hypersecretion in the symptoms of these disorders because they share several features of pathogenesis and treatment. In this article, recent important articles reporting insights into their diagnosis, pathogenesis, and treatment are reviewed. Particular attention is paid to Zollinger-Ellison syndrome, because it has the most extreme acid hypersecretion of this group of disorders and because numerous recent articles deal with various aspects of the diagnosis, molecular pathogenesis, and treatment of the gastrinoma itself or the acid hypersecretion. Two new hypersecretory disorders are reviewed: rebound acid hypersecretion after the use of proton pump inhibitors and acid hypersecretion with cysteamine treatment in children with cystinosis.
摘要
胃酸分泌过多状态的特征是胃酸基础分泌过多，历史上包括与高胃泌素血症、高组胺血症相关的疾病以及病因不明的疾病。尽管胃酸分泌很少被测量，但认识到胃酸分泌过多在这些疾病症状中的作用很重要，因为它们在发病机制和治疗方面有几个共同特征。在本文中，回顾了近期报道有关这些疾病诊断、发病机制和治疗见解的重要文章。特别关注卓-艾综合征，因为它在这组疾病中胃酸分泌过多最为严重，而且近期有大量文章涉及胃泌素瘤本身的诊断、分子发病机制和治疗或胃酸分泌过多的各个方面。还回顾了两种新的分泌过多性疾病：使用质子泵抑制剂后的反弹性胃酸分泌过多和胱氨酸病患儿使用半胱胺治疗后的胃酸分泌过多。
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