National Institute of Immunohaematology, KEM Hospital, Parel, Mumbai, India.
Clin Appl Thromb Hemost. 2010 Dec;16(6):698-700. doi: 10.1177/1076029609351290. Epub 2009 Nov 10.
We assessed the clinical manifestations in upper and lower limb deep venous thrombosis patients from India and difference in etiological factors. Fifty-three patients with primary upper extremity deep vein thrombosis (UEDVT; males 30, females 23) and 236 patients with lower limb deep vein thrombosis (LLDVT; males 157, females 79) were included in this study. The thrombophilia markers studied were protein C (PC), protein S (PS), antithrombin (AT) III, and factor V Leiden (FVL) mutation. Females had significantly higher prevalence of prothrombotic markers as compared to males (P = .046) in the UEDVT group. No statistically significant differences in the prevalence of prothrombotic markers were observed between the LLDVT and the UEDVT patients. The clinical picture however revealed greater involvement of thrombus of the iliofemoral vein (P = .009) and the proximal tibial vein (P = .005) in males than females, while no differences were observed in the clinical manifestations between the 2 sexes in UEDVT patients. Our study is able to give a broad perspective of the prevalence data of UEDVT and LLDVT in the city of Mumbai of approximately 5 million population served by this hospital. We conclude that the topology of thrombosis in deep vein thrombosis (DVT) patients in India is different from that of the Western countries.
我们评估了来自印度的上肢和下肢深静脉血栓形成患者的临床表现和病因学因素的差异。本研究纳入了 53 例原发性上肢深静脉血栓形成（UEDVT；男性 30 例，女性 23 例）和 236 例下肢深静脉血栓形成（LLDVT；男性 157 例，女性 79 例）患者。研究的血栓形成标志物包括蛋白 C（PC）、蛋白 S（PS）、抗凝血酶 III（AT）和因子 V 莱顿突变（FVL）。与男性相比，女性 UEDVT 患者中促血栓形成标志物的患病率明显更高（P=0.046）。在 LLDVT 和 UEDVT 患者中，促血栓形成标志物的患病率无统计学差异。然而，在 UEDVT 患者中，男性血栓更常累及髂股静脉（P=0.009）和近端胫静脉（P=0.005），而在男女患者中，临床表现无差异。本研究能够提供一个关于孟买市大约 500 万人口的 UEDVT 和 LLDVT 患病率的广泛视角。我们的结论是，印度深静脉血栓形成（DVT）患者的血栓拓扑结构与西方国家不同。
