Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India.
Pharmacol Rep. 2009 Sep-Oct;61(5):870-6. doi: 10.1016/s1734-1140(09)70143-4.
The relationship between systemic cytokine release and chronic beta-adrenergic activation-induced left ventricular dysfunction (LVSD) has not been widely reported in the literature. In the present study,we examined changes in the serum levels of inflammatory cytokines (IL-1-beta, IL-6 and TNF-alpha) following chronic beta-adrenergic activation-induced LVSD. Male Wistar rats were administered isoproterenol (ISO, 5 mg/kg, sc, once daily) for 4 weeks (ISO 4) or 12 weeks (ISO 12). Echocardiography was done and serum levels of IL-1-beta, IL-6 and TNF-alpha were estimated at the end of each protocol. In the ISO 4 group, there was a significant increase in relative wall thickness (p < 0.01) and heart weight: body weight ratio (p < 0.001) without any significant changes in fractional shortening (FS) or serum cytokine levels. However, in the ISO 12 group, there was a 32% decrease in FS along with increased serum levels of IL-1-beta and TNF-alpha. The present findings indicate that LVSD induced by chronic beta-adrenergic activation in rats is accompanied by increased serum cytokine levels.
慢性β肾上腺素能激活引起的左心室功能障碍（LVSD）与全身细胞因子释放之间的关系在文献中尚未广泛报道。在本研究中，我们研究了慢性β肾上腺素能激活引起的 LVSD 后血清中炎症细胞因子（IL-1-β、IL-6 和 TNF-α）水平的变化。雄性 Wistar 大鼠给予异丙肾上腺素（ISO，5mg/kg，sc，每天一次）4 周（ISO4）或 12 周（ISO12）。在每个方案结束时进行超声心动图检查，并估计血清中 IL-1-β、IL-6 和 TNF-α的水平。在 ISO4 组中，相对壁厚度（p<0.01）和心脏重量：体重比（p<0.001）显著增加，而分数缩短（FS）或血清细胞因子水平没有任何显著变化。然而，在 ISO12 组中，FS 下降了 32%，同时血清中 IL-1-β和 TNF-α水平升高。本研究结果表明，大鼠慢性β肾上腺素能激活引起的 LVSD 伴有血清细胞因子水平升高。
