Department of Animal Physiology, Institute of Biology, Maria Curie-Skłodowska University, Akademicka 19, PL 20-033 Lublin, Poland.
Pharmacol Rep. 2009 Sep-Oct;61(5):930-4. doi: 10.1016/s1734-1140(09)70151-3.
The convulsant action of cocaine and the proconvulsant effects of sildenafil, a drug which is widely used in the treatment of erectile dysfunction, have been documented both in humans and mice. Since it was reported that sildenafil alone, and in conjunction with cocaine, is used recreationally, the present study was performed to examine the influence of sildenafil on cocaine-induced seizures in mice.We showed that administration of sildenafil (5-20 mg/kg, ip) did not affect latency to clonic seizures induced by ip administration of cocaine at a dose of 85 mg/kg, nor did it influence seizure incidence and mortality.We conclude that sildenafil does not significantly increase the risk of seizures when co-administered with cocaine.
可卡因的惊厥作用和广泛用于治疗勃起功能障碍的药物西地那非的促惊厥作用已在人类和小鼠中得到证实。由于有报道称西地那非单独使用和与可卡因一起使用是娱乐性使用的，因此进行了本研究以检查西地那非对小鼠可卡因诱导的惊厥的影响。我们表明，给予西地那非（5-20 mg/kg，ip）不会影响 ip 给予 85 mg/kg 可卡因诱导的强直-阵挛性发作的潜伏期，也不会影响发作发生率和死亡率。我们的结论是，西地那非与可卡因同时使用时不会显著增加癫痫发作的风险。
