Department of Food and Nutrition, Daegu University, Gyeongsan city, Gyeongbuk, South Korea.
Eur J Clin Nutr. 2010 Feb;64(2):169-75. doi: 10.1038/ejcn.2009.131. Epub 2009 Nov 11.
BACKGROUND/OBJECTIVES: Obesity has been identified as an important factor of elevated alanine aminotransferase (ALT), a surrogate of non-alcoholic fatty liver disease. We investigated the relationship between obesity and elevated ALT in the general Korean population.
SUBJECTS/METHODS: The study sample was comprised of 3098 Korean adults who had participated in the 2005 Korean National Health and Nutrition Examination Survey. Obesity was assessed using body mass index (BMI). Overweight (23< or =BMI<25) and obese (BMI> or =25) were defined by the International Obesity Task Force for Asian adults. ALT was measured by enzymatic methods. Elevated ALT was defined as an enzyme activity >40 IU/l for men and >31 IU/l for women.
Among participants, 246 (12.7%) men and 86 (7.4%) women displayed elevated ALT. BMI was significantly higher in men and women with elevated ALT than those with normal ALT (P<0.0001). The unadjusted odds ratio (OR) for elevated ALT increased according to the degree of BMI in men (OR: 1.9, 95% confidence interval (CI): 1.25-2.93 in overweight vs OR: 5.01, 95% CI: 3.49-7.21 in obese; P<0.0001) and women (OR: 2.44, 95% CI: 1.24-4.82 vs OR: 3.94, 95% CI: 2.18-7.13; P<0.0001). This trend did not differ after adjustment for putative risk factors including alcohol intake in men (OR: 1.56 vs OR: 3.47, P<0.0001) and women (OR: 1.55 vs OR: 3.10, P=0.0015).
BMI is implicated as a strong risk factor of elevated ALT in non-diabetic Korean adults.
背景/目的：肥胖已被确定为丙氨酸氨基转移酶（ALT）升高的一个重要因素，ALT 是一种非酒精性脂肪性肝病的替代指标。我们在一般韩国人群中研究了肥胖与 ALT 升高之间的关系。
受试者/方法：研究样本由 3098 名参加了 2005 年韩国国家健康和营养检查调查的韩国成年人组成。体重指数（BMI）用于评估肥胖。超重（23≤BMI<25）和肥胖（BMI≥25）由亚洲成年人国际肥胖工作组定义。ALT 采用酶法测定。酶活性男性>40IU/L、女性>31IU/L 定义为 ALT 升高。
在参与者中，246 名男性（12.7%）和 86 名女性（7.4%）显示 ALT 升高。与 ALT 正常者相比，ALT 升高者的 BMI 显著更高（男性和女性均 P<0.0001）。男性（超重 OR：1.9，95%置信区间（CI）：1.25-2.93 vs 肥胖 OR：5.01，95% CI：3.49-7.21；P<0.0001）和女性（超重 OR：2.44，95% CI：1.24-4.82 vs 肥胖 OR：3.94，95% CI：2.18-7.13；P<0.0001）中，ALT 升高的比值比（OR）随 BMI 程度的增加而增加。这种趋势在男性（OR：1.56 vs OR：3.47，P<0.0001）和女性（OR：1.55 vs OR：3.10，P=0.0015）中调整了包括酒精摄入在内的潜在危险因素后仍然存在。
BMI 是韩国非糖尿病成年人 ALT 升高的一个强有力的危险因素。
