Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia.
Eur J Clin Nutr. 2010 Feb;64(2):176-83. doi: 10.1038/ejcn.2009.129. Epub 2009 Nov 11.
BACKGROUND/OBJECTIVES: Little is known about nutritional factors that influence circulating concentrations of steroid hormones, which are consistently associated with risk of breast cancer for postmenopausal women. We aimed to investigate the association between consumption of animal products and the plasma concentrations of steroid hormones and sex hormone-binding globulin (SHBG).
SUBJECTS/METHODS: Cross-sectional analysis was conducted on plasma from 766 naturally postmenopausal women. We measured plasma concentrations of steroid hormones and SHBG, and estimated dietary intakes using a 121-item food frequency questionnaire. Log-transformed values of hormone concentrations were regressed on quartiles of intake of meat and dairy products among food items, and fats, proteins and cholesterol among nutrient intake.
Total red and fresh red meat consumption was negatively associated with SHBG levels (P for trend=0.04 and <0.01, respectively). Mean SHBG concentrations were approximately 8% and 13% lower for women in the highest quartile compared with the lowest quartile of total red and fresh red meat consumption, respectively. Positive associations were observed between dairy product consumption and total and free estradiol concentrations (P for trend=0.02 and 0.03, respectively). Mean concentrations of total and free estradiol were 15 and 14% higher for women in the highest quartile of dairy product consumption than for those in the lowest quartile, respectively. No associations were observed with consumption of processed meat, chicken, fish, eggs, cholesterol, fats or protein.
Our study suggests that greater consumption of total red and fresh red meat and dairy products might influence circulating concentrations of SHBG and estradiol, respectively. Confirmation and further investigation is required.
背景/目的：对于影响绝经后女性循环类固醇激素浓度的营养因素知之甚少，而这些激素与乳腺癌风险始终相关。我们旨在研究动物产品的摄入与类固醇激素和性激素结合球蛋白（SHBG）的血浆浓度之间的关系。
受试者/方法：对 766 名自然绝经后的女性进行了横断面分析。我们测量了血浆中类固醇激素和 SHBG 的浓度，并使用包含 121 种食物的食物频率问卷来估计饮食摄入量。将激素浓度的对数值与食物中肉类和奶制品以及营养素中脂肪、蛋白质和胆固醇的摄入量四分位数进行回归。
总红肉类和新鲜红肉类的摄入量与 SHBG 水平呈负相关（趋势 P 值分别为 0.04 和 <0.01）。与总红肉类和新鲜红肉类摄入量最低四分位数的女性相比，摄入量最高四分位数的女性 SHBG 浓度分别低约 8%和 13%。奶制品的摄入量与总雌二醇和游离雌二醇的浓度呈正相关（趋势 P 值分别为 0.02 和 0.03）。与奶制品摄入量最低四分位数的女性相比，摄入量最高四分位数的女性总雌二醇和游离雌二醇的浓度分别高 15%和 14%。加工肉类、鸡肉、鱼类、鸡蛋、胆固醇、脂肪或蛋白质的摄入量与上述指标均无关联。
我们的研究表明，总红肉类和新鲜红肉类以及奶制品的摄入量增加可能分别影响 SHBG 和雌二醇的循环浓度。需要进一步确认和研究。
