在 Harvey 弧菌中对多种 AI-2 类似物进行的生物筛选表明，参与 AI-2 和类似物协同激动作用的受体是混杂的。
Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous.
机构信息
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
出版信息
Chem Commun (Camb). 2009 Dec 7(45):7033-5. doi: 10.1039/b909666c. Epub 2009 Oct 13.
DOI:10.1039/b909666c
PMID:19904385
Abstract
C1-alkyl AI-2 analogues do not induce bioluminescence in V. harveyi on their own but enhance the bioluminescence induced by AI-2 in a synergistic fashion. A new facile synthesis of AI-2 facilitates the synthesis of a diverse set of AI-2 analogues and biological screening suggests that receptors that are involved in the synergistic bioluminescence production in V. harveyi are promiscuous.
摘要
C1- 烷基 AI-2 类似物本身不能诱导 V. harveyi 发光，但以协同方式增强 AI-2 诱导的发光。AI-2 的新简便合成方法促进了一系列 AI-2 类似物的合成，生物筛选表明，参与 V. harveyi 协同发光产生的受体是混杂的。
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